welcome to the Corinna Burger

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  1. Hullinger, R., and Burger, C.   (2015). Learning impairments identified early in life are predictive of future impairments associated with aging. Behav Brain Res. 294:224-33.
  2. Hullinger, R., O’Riordan, K., and Burger, C. (2015). Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k. Neurobiol. Learn. Mem. 125:126-134.
  3. Li, M., Pehar, M., Liu Y., Bhattacharyya A., Zhang, S-C., O’Riordan, K.J., Burger, C., D’Adamio, L., and Puglielli, L. (2015). The Amyloid Precursor Protein (APP) Intracellular Domain Regulates Translation of p44, a Short Isoform of p53, through an IRES-Dependent Mechanism. Neurobiology of Aging. 36:2725-36
  4. Lee YS, Ehninger D, Zhou M, Oh JY, Kang M, Kwak C, Ryu HH, Butz D, Araki T, Cai Y, Balaji J, Sano Y, Nam CI, Kim HK, Kaang BK, Burger C, Neel BG, Silva AJ. (2014). Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat Neurosci. Dec;17(12):1736-43.
  5. O’Riordan, K., Gerstein, H., Hullinger, R., Burger C. (2014). Homer1c is required for mGluR5-mediated Hippocampal Plasticity Hippocampus. epub 2013 Oct 25. 24:p. 1-6.
  6. Osting, S., Bennett, A., Power, S., Wackett, J., Hurley, S.A., Alexander, A.L., Agbandje-Mckena, M., and Burger, C. (2014).  Differential Effects of Two MRI Contrast Agents on the Integrity and Distribution of rAAV2 and rAAV5 in the Rat Striatum. Mol. Ther. Methods and Clinical Development 1, 4; doi:10.1038/mtm.2013.4.
  7. Hullinger, R., Ugalde, J., Purón-Sierra, L., Osting, S. Burger, C. (2013). The MRI contrast agent gadoteridol enhances distribution of rAAV1 in the rat hippocampus. Gene therapy 20:1172-7.
  8. Gerstein, H., Lindstrom, M.J., and Burger, C. (2013). Gene delivery of Homer1c rescues spatial learning in a rodent model of cognitive aging. Neurobiol. Aging 34: 1963-1970. Epub Mar 21.
  9. Gerstein, H., Hullinger, R., Lindstrom, M.J., and Burger, C. (2013). A Behavioral Paradigm to Evaluate Hippocampal Performance in Aged Rodents for Pharmacological and Genetic Target Validation. PLoS One May 7;8(5) e62360.
  10. Potter, W., O’Riordan. K.J., Kirchner, A., Gerstein, H., Rutecki, P., Burger, C., and Roopra, A. (2013). Reduced juvenile long term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling. PLoS Biology. August 15, 11(8) e1001627.
  11. Gerstein. H., O’Riordan, K.,  Osting, S., Schwarz, M., and  Burger, C. (2012). Rescue of Synaptic Plasticity and Spatial Learning Deficits in the Hippocampus of Homer1 Knockout Mice by Recombinant Adeno-Associated Viral Gene Delivery of Homer1c. Neurobiol. Learn. Mem. 97:17-29. Epub 2011 Sep 14
  12. Westmark C.J., Westmark P.R., O'Riordan K.J., Ray B.C., Hervey C.M., Salamat M.S., Abozeid S.H., Stein K.M., Stodola L.A., Tranfaglia M., Burger C., Berry-Kravis E.M., Malter J.S. (2011).  Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1 Mice. PLoS One. October 26;6(10):e26549.
  13. Westmark, P.R., Westmark, C.J., Wang, S., Levenson, J.M., O’Riordan K., Burger, C., and Malter, J.S. (2010).  Pin1 and PKMζ sequentially control dendritic protein synthesis. Science Sign. 3, ra18.
  14. Potter, W.B.,  O’Riordan, K.J, Barnett, D., Osting, S.M.K., Wagoner, M., Burger, C.  and Roopra, A. (2010).  Metabolic Regulation of neuronal plasticity by the energy sensor AMPK. PLoS One Feb 1;5(2):e8996.
  15. Pehar, M., O’Riordan, K.J.,  Burns-Cusato, M., Andrzejewski, M.E.,  Li, H., Gil del Alcazar, C.,  Burger, C., Scrable, H., and Luigi Puglielli (2010).  The longevity-assurance activity of the p53:p44 system causes a selective degeneration of memory-forming and -retrieving areas of the mouse brain and early death. Aging Cell. 9:174-190.
  16. Burger, C. (2010). Region-Specific Genetic Alterations in the Aging Hippocampus: Implications for Cognitive Aging. Front Ag Neurosci 2:140. 
  17. Galleguillos, D., Fuentealba, J.A., Gómez, L.M., Saver, M., Nash, K., Burger, C., Gysling, K., and Andrés, M.E. (2010).  Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain. J. Neurochem.  114:1158-67.
  18. Manfredsson, F.P., Burger, C., Rising, A.C., Hasonal, K., Sullivan, L.F.,Lewin, A.S., Huang, J., Piercefield,. E., Muzyczka, M.,  and Mandel, R.J. (2009).  Tight Long-Term Dynamic Doxycycline Responsive Nigrostriatal GDNF Using a Single rAAV Vector.  Mol Ther. 17: 1857-1867
  19. Peden, C.S., Manfredsson F.P., Reimsnider S.K., Poirier A.E., Burger, C., Muzyczka, N., Mandel R.J. (2009).  Striatal Readministration of rAAV Vectors Reveals an Immune Response against AAV2 Capsids That Can Be Circumvented.  Mol Ther. 17:524-37.
  20. Burger, C., Lopez, M.C., Baker, H.V., Mandel, R.J., and Muzyczka N (2008).  Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus. Neurobiol. Learn.Mem. 89:379-396.
  21. Manfredsson, F.P., Burger, C., Muzyczka, N., Sullivan, L.F., Lewin, A.S., and Mandel, R.J (2007). rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson’s disease.  Exp. Neurol. 207:289-301.
  22. Burger, C., Lopez, M.C., Feller, J.A., Baker, H.V., Muzyczka N., and Mandel, R.J. (2007).  Changes in transcription within the CA1 field of the hippocampus are associated with age related memory impairments. Neurobiol. Learn. Mem.  87, 2007, 21-41.
  23. Eslamboli, A., Romero-Ramos, A., Burger, C., Bjorklund,T., Muzyczka,N., Mandel,R.J., Baker,H., RidleyR.M., and Kirik, D (2007). Long-term consequences of human alpha-synuclein over-expression in the primate ventral midbrain. Brain Mar;130(Pt 3):799-815.Epub 2007 Feb 15.
  24. Burger, C., Nguyen, F.N., Deng, J., and Mandel, R.J. (2005).  Systemic mannitol-induced hyperosmolality amplifies rAAV2 mediated striatal transduction to a greater extent than local co-infusion. Mol Therapy  11, 327-331.
  25. Carlsson, T., Winkler, C., Burger, C., Muzyczka, N., Mandel, R.J., Cenci, M.A., Bjorklund, A, and Kirik, D (2005).  Reversal of dyskinesias in an animal model of Parkinson’s disease by continuous L-DOPA delivery using recombinant AAV vectors. Brain 128: 559-569.
  26. Eslamboli, A.,  Georgievska, B., Ridley R.M., Baker H.F., Muzyczka, N., Burger, C., Mandel, R.J., Annett, L., Kirik D. (2005).   Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant Adeno-Associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson’s disease.  J. of Neurosci. 25: 769-777.
  27. Tümer, N., Scarpace, P.J., Dogan, M.D., Broxon, C.S., Matheny, M., Yurek, D.M., Peden, C., S., Burger, C., Muzyczka, N., and Mandel, R.J. (2006).  Hypothalamic rAAV mediated GDNF gene delivery ameliorates age-related obesity.  Neurobiology of Aging 27:459-470.
  28. Burger, C., Gorbatyuk, O, Velardo, M.J., Williams, W., Peden, C., Williams, I., Zolotukhin, S., Reier P., Mandel, R., and Muzyczka, N (2004).  Recombinant AAV viral vectors with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system.  Mol. Therapy  10, 302-317.
  29. Velardo M.J., Burger C., Williams P.R., Baker H.V., Lopez C., Mareci, T., White T, Muzyczka N., Reier P.J. (2004).  Patterns of gene expression reveal a temporally orchestrated wound healing response in the injured spinal cord.  J. of Neurosci.  24, 8562-8576.
  30. Peden, C.S., Burger, C., Muzyczkla, N., Mandel, R.J. (2004). Circulating anti-wild type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain.  J. Virol  78, 6344-6359.
  31. Eslamboli, A., Cummings, R.M., Ridley, R.M., Baker, H.F., Muzyckza, N., Burger, C., Mandel, R.J., Kirik, D., Annett L.E. (2003).  Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus).  Exp. Neurol.  184, 536-548.
  32. Kirik, D., Annett, L.E., Burger, C., Muzyczka, N., Mandel, R.J., Björklund, A. (2003). Nigrostriatal a-synucleinopathy induced by recombinant AAV vector-mediated overexpression of human a- synuclein: A new primate model of Parkinson’s disease. PNAS 100, 2884-2889.
  33. Kirik, D., Rosenblad, C., Burger, C., Lundberg, C., Johansen, T.E., Muzyczka., N., Mandel, R.J., and Björklund, A. (2002). Parkinson-like neurodegeneration induced by overexpression of a-synuclein in the nigrostriatal system. J. Neurosci.  22, 2780-2791.
  34. Kirik, D., Georgievska, B., Burger, C., Winkler, C., Muzyczka, N., Mandel, R., and Björklund, A. (2002). Reversal of motor impairments in Parkinsonian rats by continuous intrastriatal delivery of L-DOPA using AAV-mediated gene transfer. PNAS  99, 4708-4713.
  35. Ballas, N., Battaglioli, E., Andres, M.E., Atouf, F., Chenoweth, J., Anderson, M., Burger, C., Moniwa, M., Davie, J., Rose, D.W., Rosenfeld, M.G., Brehm, P., and Mandel, G. (2001). Regulation of Neuronal Traits by a Novel Transcriptional Complex.  Neuron  31, 353-365.
  36. Andres, M.E.*, Burger, C.*, Peral-Rubio, M.J.*, Battaglioli, E., Anderson, M.E., Grimes, J., Dallman, J., Ballas N., Mandel, G. (1999). CoREST: a functional co-repressor required for regulation of neural-specific gene expression.  PNAS  96, 9873-9878.   *These authors contributed equally to the work.
  37. Burger, C. and Ribera, A.B. (1996). Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development. J. Neurosci.  16, 1412-1421.Type your paragraph here.